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  • Chemical PE

    I had be contemplating waiting to write this thread until I started my new routine but I guess now is as good a time as any.

    This thread is based on the experiences of others under the care of Dr. Kenneth W. Adams from North York, Canada. He is the holder of a patient for penis enlargement through the use of pharmaceuticals . His site is Welcome - Doctors 4 Men The patient can be found here. United States Patent Application: 0050065159

    Here are the highlights of the process:

    Abstract

    A method for causing a permanent increase in the length and girth of a male subject's penis, the method comprising treatment comprising the step of (a) administering to the male an effective amount of a vasodilator selected from the group consisting of a vasodilator per se and compositions thereof comprising a pharmaceutically-acceptable diluent or carrier, to induce a cumulative prolonged engorgement of the subject's penis; and (b) repeating step (a) as necessary to cause the increase during the treatment. A potentiator which enhances the effect of the vasodilator may also be used


    SUMMARY OF THE INVENTION
    [0007] In a first aspect, this invention provides a pharmaceutical vasodilator which induces a cumulative prolonged engorgement of a human penis, optionally as a composition together with a pharmaceutically-acceptable diluent or carrier, for use in causing a permanent increase in size of the human penis. As explained in greater detail below, the permanent increase in size is achieved by repeated use of the vasodilator or composition thereof, say, once a day for a few days a week over many weeks, possibly many months.

    [0008] In accordance with another aspect of this invention, there is provided a method of enhancing penis size by administering said vasodilator or composition thereof so as to induce a cumulative prolonged engorgement of the penis. According to the method, such an administration lasts for a limited time during one day, and is repeated up to daily or a few days a week over a period of several weeks.



    The process involves injecting a vasodilator in the corpus cavernosa of the penis to stimulate an prolonged erection and a peptide to stimulate smooth muscle growth. The patent mentions multiple variations of the process and substances involved. This is mostly likely to protect from infringement of the patent with other chemicals.

    This goal is a prolonged erection. This prolonged erection with PGE-1 (prostaglandin) weakens the collagen cross-linking in the tunica allowing for deformation of the tunica. The enlargement process involves stretching exercises as with conventional PE. Men suffering from ED have been injecting with PGE-1 for years without any penile enlargement. The exercises are key and without them no enlargement takes place.

    The second component of the formula is IGF-1 LR3. IGF-1 (Insulin-like Growth Factor) is a peptide produce in the liver from the absorption of HGH (human growth hormone) and has been used for years by bodybuilders to enlarge their muscles. IGF-1 LR3 is not approved for human use. It is a media grade, research chemical and as such carries some degree of risks. IGF-1 LR3 is an altered version manufactured in laboratories that modifies the IGF-1 that occurs naturally in the body. IGF-1 LR3 (Long R3 Insulin-like Growth Factor-I or Long R3IGF-I) is an 83 amino acid analog of human IGF-I actually comprising the complete human IGF-1 sequence but with the substitution of an Arg for the Glu at position 3, as well as a 13 amino acid extension peptide at the N-terminus. This makes Long R3IGF-I significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body. Many guys inject the IGF-1 along with the PGE-1 to avoid multiple injections.

    What does IGF-1 LR3 do? It binds to muscle cells and causes them to multiply. From the results, it appears that IGF-1 LR3 is equally binding to smooth muscle cells as it is to skeletal muscle cells. Hence it is effective at increase smooth muscle mass in the penis.



    EXAMPLE 1

    [0080] A male patient, age 41, was treated with intracavernosal injections of a vasodilator, prostaglandin E1, on a regular basis (approximately four to five times per week) over an 18 month treatment period. A sufficient quantity was administered to maintain a prolonged engorgement of an erectile response between 40-75% over a period of several hours, generally 3 to 6 hours. The quantity of medication was adjusted from time to time in accordance with the patient's response, which was monitored at least weekly.

    [0081] The size of the patient's fully erect penis increased from 5.8 inches to 8.6 inches in length (about an 48% increase) and 3.7 inches to 5.8 inches in girth (about an 56% increase) over the 18-month treatment period. Following the discontinuation of this treatment, the erect penis length remained stable for two years at over 81/2 inches. Treatment was re-institued combining intracavernosal injections 3-4 times per week of a mixture of testosterone (0.5 mg) and vasodilators with low dose oral Potaba (500-1000 mg) 3-4 times per day. After a short treatment period of 21/2 months, the patient's erect penis was over 9 inches in length, which means he has gained an additional 0.4-0.5 inches in length (about an 6% increase). The total increase in length was therefore about 3.2 inches (about an 55% increase) in length.
    [/quote]

    If these examples are indeed true, and I have every reason to believe they are, then the potential is huge. I am familiar and in contact with a few of Dr Adams patients and they are reporting significant gains from this process. One such individual has gained 2" in length and 1" in girth in just over 14 months. He actually had to stop the IGF-1 LR3 due to not wanting larger girth.

    Before you rush out and attempt this you must be forewarned this carries some serious risks and is definitely not for everyone. The cost is substantial and although it doesn't require it, it should be done under the supervision of a doctor. One such risk is priapism. Nearly everyone who has attempted this route has experienced a priapism. If you are not familiar with the dangers do a little research. Although highly unlikely, the worse case scenario is death. One guy just
    returned from the ER last night with an 8 hour erection. It scared the daylights out of him. Another risk is fibrosis from the injections. Although the risks are small, they are still a real danger. PGE-1 being the least likely to cause fibrosis/Peyronie's disease, Papaverine being the most risky.

    I have visited with my urologist and it appears that he will likely start me on the PGE-1 injections my next visit. I plan on placing my order for IGF-1 LR3 tomorrow. My plan is to start sometime around the first or middle of May. I am planning on keeping my progress posted in my current log.

    The purpose of this post is to inform you of what's available. I am not suggesting any of you run out and try this. This is not for the do-it-yourself guy that wants a quick fix. The dangers are real and you only have one penis. If you even contemplate trying this do yourself a favor and do it under the supervision of a physician. I would hate to think I contributed to someone injuring themselves.

    I kind of threw this thread together. I will keep reviewing and editing to try to make the information more presentable and easy to follow, but hopefully you get the general idea.

    I should have all my supplies within 2-3 weeks, prohibiting any unforeseen occurrences. I will keep you updated.


    -Iguana
    Iguana
    Senior Member
    Last edited by Iguana; 10-06-2010, 03:34 PM.
    May 2006: 5.75" X 4.5" - Now: 7.44" X 4.875"


    Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

    Louis Pasteur

  • #2
    Yes, that was interesting. Please do, keep us informed.

    I've got a Tiger by the tail.

    Comment


    • #3
      unless you have ED i do not see why you would want to use chemicals to enhance yourself when there is a natural way to do it
      no matter what research says, anytime you inject somthing into your body that isnt naturally there, you are taking an unneccessary risk
      keep in mind that you used to be able to buy crystal meth in pharmacies....
      just because there are no short term side effects doesnt mean it wont have any long term effects
      this could effect your children or your grandchildren
      just my two cents....
      i got BIG hopes.. get it.. BIG hopes... like a BIG penis.. get it.. god ur stupid..

      Comment


      • #4
        Very true, smallie. But if nobody takes risks, then we'll get nowhere. The guys who first did PE were probably told the same thing: I don't see why you're jelqing your penis, your enter arbitrary number here inches is already big enough (hell, mainstream media still says this).

        I'm not suggesting the average guy use chemicals with PE, but Iguana is well informed about all matters relating to the penis. He knows what he's doing.

        How much did it cost, Iguana?
        "Insanity: doing the same thing over and over again and expecting different results." - Albert Einstein

        Comment


        • #5
          Yep, I agree. We need Iguana Pigs to open new vista's for the PE communities.

          I've got a Tiger by the tail.

          Comment


          • #6
            Originally posted by smallie View Post
            unless you have ED i do not see why you would want to use chemicals to enhance yourself when there is a natural way to do it no matter what research says, anytime you inject somthing into your body that isnt naturally there, you are taking an unneccessary risk keep in mind that you used to be able to buy crystal meth in pharmacies....
            just because there are no short term side effects doesnt mean it wont have any long term effects this could effect your children or your grandchildren just my two cents....

            smallie,

            Thanks for your reply and concern. You have valid arguments and reasonings and that is precisely why I wrote the stern warning about the risks. I emphasized worse case scenarios in an effort to discourage young do-it-yourself types that have a feeling of invinciblitiy. There certainly are risks involved with this or, as remek pointed out, any type of PE. However, if done properly and intelligently it is rather safe.

            Men have been injecting themselves safely with ED medications for years. The risks and complications arise from not knowing what you are doing or taking unnecessary risks out of impatience. Proper education and training is the key to safety. Let's take a look at the potential problems that might occur.

            From PGE-1 (or any other vasodilator) injections:

            Priapism - priapism is an erection lasting more than 4 hours. It can be the result of over dosing with the prescribed vasodilators. Why is this dangerous? For an erection to occur, blood is trapped in the penis from the constriction of veins. Without fresh blood circulating in the penis, the tissue becomes oxygen starved and begins to die. If left unchecked the tissue necrosis can set up gangrene and lead to death. This is the doomsday version of what could happen. The good new is, that if titrated properly, the dosage should not propose a problem. In the rare event of a priapism, there are certain things that can help such as taking Sudafed with Pseudoephedrine in it. Caution should be exercised as some newer versions of Sudafed do not contain Pseudoephedrine. The ones that do usually are kept behind the counter due to meth manufacturing issues. In any event after 4 hours with an erection a trip to the ER may be necessary. They can give you an injection that will bring the erection down.

            Worse can scenarios happen to the stubborn or foolish that think they don't need a doctor. Check out this post if you a feeling you could handle a prolonged priapism... https://www.pegym.com/forums/10925-post2.html

            Fibrosis - Fibrosis or Peyronie's disease has been linked to repeated injections of vasodilators over months or years. The main culprit is Papervine. There are also cases with PGE-1 but these are much rarer. In any case, if you notice any signs of fibrosis discontinue the injections.

            From IGF-1 LR3

            IGF-1 LR3 is a growth hormone. IGF-1 is produced naturally by the liver from the metabolizing of HGH (human growth hormone) so this product already occurs naturally in the body. The modified version IGF-LR3 simply increases the half life of the product and allows for greater binding potential.

            Risks include growth of other organs/tissues containing IGF-1 receptors such as the intestines. How much of a risk is this? Not much. The recommended dosage for penile injections is 10 to 15mcg. Bodybuilders take upwards of 60-80mcg and as much as 100mcg per day. This has resulted in what is called "perma-gut" in such BB's as Ronnie Coleman, from enlarged intestines. You have to remember, not only do these guys take large dosages, the chemical is injected directly in various muscles allow for a much greater systemic effect. The recommendation for penile injection is to wear a cock-ring or constriction device to keep the IGF-1 LR3 localized in the penis. In which case the risks for systemic effect should be minimal.

            Another risk is if you have cancer. Being that IGF-1 is a growth hormone, it can accelerate the growth rate of cancer. So, if there is a question there, it would be best not to use this product. Studies show that IGF-1 does not cause cancer, but may accelerate the growth.

            As you can see, there are risks involved in this protocol. But, like with any endeavor, caution and a bit of common sense goes a long way.


            Originally posted by JonPop View Post
            Yep, I agree. We need Iguana Pigs to open new vista's for the PE communities.
            Sure... go ahead and sacrifice him. After all he's just a stupid lizard!
            Iguana
            Senior Member
            Last edited by Iguana; 04-22-2008, 01:39 PM.
            May 2006: 5.75" X 4.5" - Now: 7.44" X 4.875"


            Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

            Louis Pasteur

            Comment


            • #7
              Originally posted by remek View Post
              Very true, smallie. But if nobody takes risks, then we'll get nowhere. The guys who first did PE were probably told the same thing: I don't see why you're jelqing your penis, your enter arbitrary number here inches is already big enough (hell, mainstream media still says this).

              I'm not suggesting the average guy use chemicals with PE, but Iguana is well informed about all matters relating to the penis. He knows what he's doing.

              How much did it cost, Iguana?
              Thanks remek! I have researched this extensively and feel it can be a safe and effective protocol.

              I have only purchased the IGF-1 so far. It was around $190 for 1mg. This should last me about 6 months. The PGE-1 prices vary by the dosage.
              It really depends on how much you need to inject. I will let you know what mine ends up costing me. I think it can range from about $2.50 - $12.50 per injection. I think the tri and quad mixes are much less than that.
              May 2006: 5.75" X 4.5" - Now: 7.44" X 4.875"


              Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

              Louis Pasteur

              Comment


              • #8
                Originally posted by Iguana View Post
                Sure... go ahead an sacrifice him. After all he's just a stupid lizard!
                Aw, man, iguana. I didn't mean anything disparaging. I was just trying to make a funny by using Iguna instead of 'Guinea' Pig. Sorry if you took that the wrong way. JP

                I've got a Tiger by the tail.

                Comment


                • #9
                  Originally posted by JonPop View Post
                  Aw, man, iguana. I didn't mean anything disparaging. I was just trying to make a funny by using Iguna instead of 'Guinea' Pig. Sorry if you took that the wrong way. JP
                  No offense at all! I was just playing along with the joke. It got a chuckle out of me.
                  May 2006: 5.75" X 4.5" - Now: 7.44" X 4.875"


                  Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

                  Louis Pasteur

                  Comment


                  • #10
                    As to the effect of PGE-1 on the tunica. Studies indicate that PGE-1 hinders collagen production and can unlink collagen fibers making the tunica easier to stretch.

                    This information seems to suggest that penile oxygen levels dictate a balance between PGE-1 and TGF-β1. Low oxygen levels trigger collagen production and fibrosis. PGE-1 seems to have the reverse effect. That's if I am reading these articles correctly. If this is the case, PGE-1 would likely be superior to other vasodilators (Papervine, phenotolamine, etc. )


                    Quote:
                    Revascularization of Myocardial Scar Tissue Following Prostaglandin E1-Therapy in Patients with Ischemic Heart Disease

                    PGE-1-treated patients had significantly more CD34- and VEGF-positive cells in infarcted areas, and showed a significant reduction in collagen content as compared with the non-PGE-1 group

                    http://www.sciencedirect.com/scienc...f021b945feb1b3f




                    Quote:
                    Fibrosis of corpus cavernosum in animals following cavernous nerve ablation

                    PGE1 suppresses the induction of collagen sythesis by transforming grouth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol 1995; 153: 826-34.

                    http://www.asiaandro.com/1008-682X/6/111.htm



                    Quote:
                    Penile Rehabilitation After Radical Prostatectomy: Important Therapy or Wishful Thinking?

                    Together, these studies suggest that the collagen content in the corpus cavernosum is regulated by oxygen tension through the increased or decreased expression of TGF-β1 and PGE1. During low oxygen tension, increased expression of TGF-β1 activates a molecular cascade to increase collagen and other connective tissue synthesis. During high oxygen tension, on the other hand, increased expression of PGE1 activates an alternate cascade to decrease collagen synthesis. To date, the data are insufficient to confirm that this delicate balance of TGF-β1 and PGE1 expression actually dictates the varying amounts of smooth muscle and connective tissue content within the corpus cavernosum at physiologic oxygen tensions.

                    http://www.pubmedcentral.nih.gov/ar...i?artid=1751036
                    May 2006: 5.75" X 4.5" - Now: 7.44" X 4.875"


                    Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

                    Louis Pasteur

                    Comment


                    • #11
                      UPDATE:

                      Received my IGF-1 LR3 today. Waiting now on my syringes and BS water. I hope to start my injections early to mid next week.
                      Still waiting on a call back from my urologist on the PGE-1 titration.
                      May 2006: 5.75" X 4.5" - Now: 7.44" X 4.875"


                      Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

                      Louis Pasteur

                      Comment


                      • #12
                        Well, good luck Iguana. Hope this proves to be a good thing for you.

                        I've got a Tiger by the tail.

                        Comment


                        • #13
                          Thank you sir! I got my bacterostatic water today, just waiting on my syringes. I plan on being of African tribe status in a few months.
                          May 2006: 5.75" X 4.5" - Now: 7.44" X 4.875"


                          Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

                          Louis Pasteur

                          Comment


                          • #14
                            Iguana: If we never hear from you again, we'll assume the worst
                            "Insanity: doing the same thing over and over again and expecting different results." - Albert Einstein

                            Comment


                            • #15
                              You can't die Iguana, I'm writing you into the next story. But if you start bragging about how big your dick is getting from this treatment, I might have to make you a stable boy. Hee

                              I've got a Tiger by the tail.

                              Comment

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