HypoProlactinaemia - Low/Deficient Prolactin in Men - Cause for Concern or Ideal?

[corageon Banned Find all posts View Profile Close corageon]

Many men have used cabergoline and similar dopaminergics in attempt to reduce or eliminate the refractory period, this has been proven...or has it? Specifically, lowering Prolactin simply raises gonadotrophin output, leading to more testosterone produced, however, nobody has really evaluated the effects of low or deficient prolactin in men.
In fact, I got the feeling that many people were searching (either out of curiosity or because of ED problems presented after Caber,Prami etc), and yet, I had to go through "loops and tunnels" to dig up this information. So I've compiled it all and I think it will be an interesting read for most of you.
In short, low prolactin/deficient prolactin is associated with.

-Low 5-alpha-Reductase; possibly simulating a Post-Fina syndrome; low DHT levels. As prolactin converts testosterone into DHT by increasing 5-AR.
-Anxiety and Premature Ejaculation; due to decreased GABA and increased excitory glutamate signaling. Glutamate stimulates Ca2+ (calcium channels) and excites the entire nervous system.
-Possible estrogen dominance and further GABA decreases and resultant anxiety, OCD, and seizure disorder/s.

HypoProlactinaemia - A new Issue in Men using Dopaminergics? Cause for Concern or Ideal Biological State?

[Dangler Senior Administrator☼ Wizard ☼ White Tiger Award 2015 Find all posts View Profile Close Dangler]

Interesting Blog article, not spammy either. Thanks for sharing it.

[corageon Banned Find all posts View Profile Close corageon]

Thanks, I Figure it will help explain some of the issues commonly complained about by users of these drugs. There's very little out there and not everyone knows how to get into researchgate and etc.

[Pegasus AdministratorPE Gym EditorPEGym Hero ☺ Admin of the Month Mar 2015 Find all posts View Profile Close Pegasus]

The refrac period can be elimated by dry orgasm and mmo . This can be learnt by training and is actively taught onsite.

[corageon Banned Find all posts View Profile Close corageon]

The refrac period can be elimated by dry orgasm and mmo . This can be learnt by training and is actively taught onsite.

Oh I know there's techniques, but you can't tell that to the "miracle pill" minds.

[corageon Banned Find all posts View Profile Close corageon]

I believe firmly that GABA is a much stronger factor both in "conditioning" and "libido"; most studies show GABA is not only necessary in regards to inhibiting prolactin, but also since Low Prolactin levels causes the loss (or significant reduction) in GABA production from glutamate, it would seem as though GABA is a much more significant "central regulator". Interestingly, GABA deficiency is also associated with social anxiety and performance anxiety and low prolactin also in the studies has led to anxiety and premature ejaculation. Thus focusing on dopamine is really irrelevant, ask anybody who has a GABA deficiency if they have any enjoyment in life (without alcohol at least)...?

Dopamine + GABA = Well-Being and Confidence...
Dopamine without GABA = Anxiety and Shitty quality of life.

[Slip Senior Member Find all posts View Profile Close Slip]

I believe firmly that GABA is a much stronger factor both in "conditioning" and "libido"; most studies show GABA is not only necessary in regards to inhibiting prolactin, but also since Low Prolactin levels causes the loss (or significant reduction) in GABA production from glutamate, it would seem as though GABA is a much more significant "central regulator". Interestingly, GABA deficiency is also associated with social anxiety and performance anxiety and low prolactin also in the studies has led to anxiety and premature ejaculation. Thus focusing on dopamine is really irrelevant, ask anybody who has a GABA deficiency if they have any enjoyment in life (without alcohol at least)...?

Dopamine + GABA = Well-Being and Confidence...
Dopamine without GABA = Anxiety and Shitty quality of life.

I have almost non-existent libido. Are you saying I could be deficient in GABA. I can get an erection, but I have to beat myself off lately, in other words, it is not getting hard by being aroused, because of the low libido.

I have hardly any confidence because of this!

[corageon Banned Find all posts View Profile Close corageon]

I have almost non-existent libido. Are you saying I could be deficient in GABA. I can get an erection, but I have to beat myself off lately, in other words, it is not getting hard by being aroused, because of the low libido.

I have hardly any confidence because of this!

You definitely could be deficient in GABA...do you also have anxiety symptoms?
You can get saliva and blood tests for GABA, and I would recommend getting a full hormone panel done. What do you think led to your loss of libido? Do you take any meds?

[corageon Banned Find all posts View Profile Close corageon]

Keep in mind the literature is kind of unclear when it comes to serotonin-GABA interactions as well, people with low prolactin also frequently have low serotonin but then again there are a hella lot of herbs that lower serotonin.
Not to mention other things in our daily lives; drug withdrawal/alcohol use - benzo withdrawal/benzo use, stress depletes serotonin....etc fasting, BULIMIA - has been shown to lower prolactin.
Some serotonin sites are more specific in their interactions with GABA - others, not so much.

[corageon Banned Find all posts View Profile Close corageon]

I should add andrenergic interactions somewhere...in some studies...it shows phenylephrine infusions had increased aromatase enzymes, as well as prolactin (probably from estrogen)......
This implies alpha-1-adrenergic receptors mediate much of this feedback..interesting how they are also involved with glutamate release.

Autonomous expression of aromatas... [J Steroid Biochem Mol Biol. 1997] - PubMed - NCBI

[corageon Banned Find all posts View Profile Close corageon]

One more thing, it should be noted that things like eGB/Ginkgo Biloba actually act to antagonize GABA-A receptors (and thus provide an anxiogenic effect), thus any enhancement of sexual function while using GBE is based on the PDE-5 inhibition and muscarinic mRNA increases.

[corageon Banned Find all posts View Profile Close corageon]

I guess there is one other article on this
Men's Sexual Problems Linked to Low Prolactin Levels

[corageon Banned Find all posts View Profile Close corageon]

It seems like there is a strong connection between oxytocin and prolactin.
The acute effects of intranasal oxy... [Psychoneuroendocrinology. 2008] - PubMed - NCBI

[corageon Banned Find all posts View Profile Close corageon]

I think the issue too with overusing dopaminergics is basically the same issue high serotonin. D(2) preferring agonists DECREASE cyclic AMP - which leads to less PKA, Glutamate,AcH and other important neurotransmitters and conductance pathways. Not to mention decreased thyroid output...which will make you feel shitty.
Using dopaminergics for "sexual enhancement" is probably the most absurd idea. They also induce Low BP and fatigue because of the above reasons. Better to go with "L-Dopa" than D(2) agonists like Caber imo.
Unless you have a REAL prolactin issue or diagnosed hyperprolactinaemia.

[corageon Banned Find all posts View Profile Close corageon]

Should also be noted that the Points in this article are not by any means suggesting a replacement for advice from the doc nor is it saying that if you have low prolactin that you should necessarily inject, or increase prolactin (that would be just absurd)...but it's simply pointing out the biochemical changes that occur with CLINICAL low prolactin (actually deficient, not just low)..