Trimix Injection: Loosing Effectiveness ??

[PundaSmith Junior Member Find all posts View Profile Close PundaSmith]

Hello, I have been using Trimix for the last 4 years. At the time, I was on the standard dose, consisting of the following:


Standard/Basic Dose


• Papaverine HCl 30 mg/ml
• Phentolamine Mesylate 1 mg/ml
• Prostaglandin E1 10 ug/ml


However, at the beginning of this year, I realized this dose was no longer effective. My regular shot all along was about 0.4 ml, but this proved ineffective. I injected more, increasing it to about 0.8ml but often got a wobble... so my uro then upgraded me to a higher dose, consisting of:


Trimix 30


• Papaverine HCl 18 mg/ml
• Phentolamine Mesylate 0.6 mg/ml
• Prostaglandin E1 30 ug/ml


But again, this was not effective. Upon injection, I get a slight erection which quickly vanishes after about 2 minutes. I increased my shot to 0.9ml, with little usable effect. So my uro just recently increased my prescription to:


Trimix 50


• Papaverine HCl 30 mg/ml
• Phentolamine Mesylate 1 mg/ml
• Prostaglandin E1 50 ug/ml


I was told to start at 0.6ml. I tried it, but got little effect. I increased it to 0.7ml, with little to no success.
Within the last week, I have injected a full syringe (0.98ml) without any usable erection -- it is not firm enough (maybe on a grade of 4 out of 10), and points south.


Is it possible, my system may be getting resistant to Trimix. Until this year, when I take Trimix, I know how it feels - the slight ache and good wood were so reliable .. but now, it looks as if the injection just enters my system and flushes out.



Any ideas, should I just continue increasing the dosage? Is it possible / advisable to increase this Trimix strength or do I have to start considering the final frontier (an implant)?


Cheers, PS

[CUSP82 Administrator Admin of the Month Dec 2014PEGym Hero Find all posts View Profile Close CUSP82]

What does your doctor say about it?

[PundaSmith Junior Member Find all posts View Profile Close PundaSmith]

When the Uro realized Trimix 30 was not working, he prescribed a custom blend of Trimix 50. but indicated that I may want to start considering an implant .. but I am hoping there is still scope for increasing the dosage, particularly the Prostaglandin - which as of now is 50ug.

thanks

[not2big Senior Super ModeratorPEGym Hero Find all posts View Profile Close not2big]

Hey PundaSmith!

Welcome to the Gym.

Unfortunately there are only a few of us at the Gym who actively inject Trimix. However, my experience is somewhat similar to yours. After three years, I just had my dose increased from 0.588 mcg of PGE1 to 1 mcg. Yet I still need to inject .4 ml instead of .5 ml of the weaker dose.

Jstars is more familiar with this subject and hopefully he will also respond to your inquiry.

i also recommend you check out franktalk.org., a forum more geared to ED issues. There you will find a forum specifically dedicated to Injections.

i personally use an Osbon tension band to strengthen my Trimix induced erection when it begins to fade. The Trimix erection is good for foreplay, but when I want to get down to the business at hand, I slip on the Osbon which brings me up to 100%.

Good luck.

[donjelqer76 Retired ModeratorPEGym Hero Find all posts View Profile Close donjelqer76]

If you have a significant other, have they tried helping with the erection (oral, etc)?

Have you tried anything beyond medications to help improve your erections? I don't have ED, but jelquing and kegels have improved my erections dramatically. Perhaps it would be worth a try to see if these types of exercises in addition to your medication could be of benefit?

[Slip Senior Member Find all posts View Profile Close Slip]

When the Uro realized Trimix 30 was not working, he prescribed a custom blend of Trimix 50. but indicated that I may want to start considering an implant .. but I am hoping there is still scope for increasing the dosage, particularly the Prostaglandin - which as of now is 50ug.

thanks

How did you ever make out. I'm in the same boat.

[Big Al AdministratorPEGym EditorMale Enhancement Coach Rep.PEGym Hero Find all posts View Profile Close Big Al]

PundaSmith,

If I may ask, what specific issue requires you to use trimix?

[Big Al AdministratorPEGym EditorMale Enhancement Coach Rep.PEGym Hero Find all posts View Profile Close Big Al]

Just saw the date on this OP. It's hoped he'll check in sometime soon.

[Pegasus AdministratorPE Gym EditorPEGym Hero ☺ Admin of the Month Mar 2015 Find all posts View Profile Close Pegasus]

It seems common for the ed medications to lose effect over time.

[Big Al AdministratorPEGym EditorMale Enhancement Coach Rep.PEGym Hero Find all posts View Profile Close Big Al]

Injecting the penis over long periods of time may lead to scar tissue build up too

[Pegasus AdministratorPE Gym EditorPEGym Hero ☺ Admin of the Month Mar 2015 Find all posts View Profile Close Pegasus]

I wish I could convince young guys seeking superman effect to use natural methods and avoid drugs . As this gentlemans experience shows when you do need them the effect may be difficult to keep going.

[shortystuff Junior Member Find all posts View Profile Close shortystuff]

I've been using injectables for over 15 years (recreational mostly) they do lose a little efficiency over time- body just needs a bit more -
but what i found was the quality of the medication,
caverject that has been exposed to heat loses power
trimix also exposed to heat/not kept cold loses power
also the compounding pharmacy that makes the tri/bi/quad/penta mix also makes a big difference on the quality of the drug, finally each batch differs sometimes you just get a bad batch and it just dont work well.

[Slip Senior Member Find all posts View Profile Close Slip]

Thanks shortystuff for this insight. I did notice that when my doctor switched up pharmacy's, the stuff just didn't seem as good ( three refills). He had to switch up, because the old pharmacy no longer makes trimix. Well I had him change it to another pharmacy. Only problem is, the pharmacy is in Florida and I'm in NC, so they have to overnight it, and that cost $30. I pick it up today, so I will test it out tonight. I will have my adjustable constriction band with me just in case. Oh, it's a quadmix too, with 120 mg or mcg of PDE1.

[not2big Senior Super ModeratorPEGym Hero Find all posts View Profile Close not2big]

Injecting the penis over long periods of time may lead to scar tissue build up too

Statistically, only about 10% of guys injecting over a significant period of time experience scar tissue build up if they followed proper injecting procedures - only two or three times a week and alternating sides.

[Saskman Senior Member Find all posts View Profile Close Saskman]

and i'd like to add, please exhaust all venues before resorting to injections; it's the last step before a penile injection. researching and discussing my own venous leak problems, i've come across so many young men who resort to either/or without adequately researching their own problem prior. i think penile injections are great if you require them, scar tissue? does it really matter so much? once you get to trimix you should have no alternatives. the natural progression is a penile implant.

there is a new drug out called muse, i think? it was alprostadil, but pellets instead of injections.

not sure if it's available in the USA or Canada yet, but it might be a great alternative that doesn't result in scar tissue at all yet does the exact same thing as Trimix.