When it comes to lifelong or primary premature ejaculation, it is most often accompanied by an underlying cause such as hormonal, neurotransmitter, vitamins or cholesterol imbalance. So as a first step, one should get tested to any underlying cause. Once this is fixed, premature ejaculation gets fixed itself. Normally premature ejaculation is accompanied with many other ailments like anxiety, depression, insomnia, hyperactive brain, hyper-sexuality, week muscles, uncontrolled muscle spasms or convulsions.
Herbalists has been using herbs and foods to cure premature ejaculation and other ailments for centuries. In this century, the medical world attributes these ailments to imbalance of chemical substances called neurotransmitters. These neurotransmitters are affected in response various conditions and mineral imbalance. You will get some useful information about neurotransmitters here.

Neurotransmitter Imbalance
NEUROTRANSMITTERS are the brain chemicals that communicate information throughout our brain and body. They relay signals between nerve cells, called “neurons.” The brain uses neurotransmitters to tell your heart to beat, your lungs to breathe, and your stomach to digest. They can also affect mood, sleep, concentration, weight, and can cause adverse symptoms when they are out of balance.

Most importantly, this imbalance causes premature ejaculation, nerve disorders, hypersensitivity, anxiety, depression and other mental illnesses. Mental illness is under diagnosed through out the world. A study showed that 42% lifelong premature ejaculators has ADHD.

Neurotransmitters control your arousal, erection and orgasm etc. Each one of us has different levels of these neurotransmitters and this determines our general behavior and personal traits.

There are excitory neurotransmitters like histamine, norepinephrine and dopamine. High levels of these cause over excitement, over arousal, over sensitivity and over activity.

There are inhibitory transmitters like serotonin and GABA. These calm your body, brain, nerves and muscles.

Balance between excitory and inhibitory neurotransmitters is very important. If the balance is in favor of excitory transmitters, then you are over excited, over thinking, anxious, ambitious, hyper-sexuals and premature ejaculator etc. You fall in Category-A personality. They have less control over their body, brain, muscles and nerves etc. They have hyper active brain.

If the balance is in favor of inhibitory transmitters, then you can enjoy good sleep, sex etc. In fact, this is what makes your personality Category-B. They have better control over their body, brain and actions.

Normally, the ultimate balance of neurotransmitters is determined by the body metabolism through a complex feedback mechanism. When you increase one neurotransmitter, your body tries to achieve the balance by reducing or enhancing other chemicals, hormones or neurotransmitters. That is why it is normally not advised to play with these chemicals unless you have some serious illness or disorder.

Neurotransmitters for Sex:
A. Serotonin, its deficiency causes premature ejaculation, anxiety and depression etc. That is why, the first thing a doctor prescribes is an SSRI drug (though it is an off-label use).
Recreational drugs and weeds including opiates etc., also increase the serotonin.
Exercising and working out muscles increase the serotonin and should be the first choice to increase serotonin.

Supplements: Griffonia Seed Extract or 5-HTP, St. Johns Wort, L-Tryptophan, Ashwagandha, Vitamin B-Complex.

B. GABA is the second most important neurotransmitter. Lack of it makes the nerves hyperactive and causes premature ejaculation, insomnia, restless legs syndrome, bipolar disorder, nerve control and motor control disorders etc. Severe deficiency of it causes epilepsy. If drinking alcohol makes you last long, increasing GABA will most probably help you last long. Alcohol increases GABA in the brain temporarily. Psychotic drugs like Valium also increase GABA. But these are addictive at the same time drugs.

Taking vinegar 1 teaspoon before every meal increases GABA. Valproate (valproic acid) is more better than vinegar as it does not get digested within minutes like vinegar. Lithium also works.

Supplements: Glutamine, Valerian, Green tea or L-Theanine, St. John's Wort, Vitamin B6, Magnesium, Passion Flower, Ashwagandha, Kava-Kava. Almonds, Walnuts are also good foods. Melatonin also increases GABA.

(You know there are sleep pills which increase the GABA but these are habit forming. Passion Flower or Passiflora in homeopathy is known as herbal valium. So it seems a good choice to increase GABA)

Tip: Lower your glutamate levels with Vit K2 and B6.

C. High levels of Histamine:
It is big culprit. It causes inflammation, allergies and makes the nerves, muscles, and prostate over sensitive. It causes premature ejaculation, anxiety, over stimulation, aggressiveness, compulsive and a racing brain, high libido, allergies, and low muscle tone. Easy orgasm and high libido is a major symptom of high histamine "histadelia". A saliva or blood test can be done to check your histamine levels. In homeopathy, the term "Sulfur Patient" is used. You can google these terms and find out more detailed symptoms. I think high levels of histamines is a big factor in premature ejaculation (if not the prime factor).

According to "The Amino Revolution" book, premature ejaculation in younger males is due to high levels of histamine.

Dr. Pfeiffer mentioned premature ejaculation as a symptom of histadelia in his book (page 155). This topic is worth reading. On page 160, he prescribes following to lower the histamine:
In summary, the treatment program for histadelia is:
1. Vitamin C 1.0 gm AM & PM
2. Vitamin B-6 to normal dream recall
3. DL-Methionine 500 to 1000 mg AM & PM
4. Calcium salt 500 mg AM & PM
5. Phenytoin (Dilantin) 100 mg AM & PM
6. Low protein diet
7. Avoid multivitamins and folic acid

Here is another document which describes to lower histamine levels using Methionine, L-Arginine, Vitamin C, Vitamin B6 and calcium etc. Here is another article to lower histamine levels.

Here is a list of histamine lowering foods. Some of these are often found in premature ejaculation supplements.
Sulfur rich foods (like ginger, garlic, onions, turmeric, eggs, cauliflower, broccoli) are good to reduce histamine. Quercetin, Nyquil, butterbur, Thyme also lowers histamine.
Remember these foods are very popular among some communities.

Most effective supplements are MSM, SAMe, Methionine, L-Arginine/Citrulline, Calcium, Vitamin-C, inositol, TMG, and zinc.
Avoid: Folic Acid, Alcohol, Histadine, Sugar
Delayed ejaculators are given histadine to increase histamine levels and cure DE.

D. Dopamine is a pleasure and motivation neurotransmitter.
High levels cause over excitement and over arousal and therefore cause premature ejaculation. If your refractory period is low and you have throbbing erections, then you are high in dopamine.

If you have erection problems or ED, then you are surely not high in dopamine.
Anxiety, psychosis, addiction, compulsion, gambling, aggression and unhealthy risk taking are some symptoms associated with increased levels of dopamine.
Here a study where a prescription drug is used to cure premature ejaculation.

Low levels of dopamine cause Parkinson's disease etc. In this case Macuna Prurens is used to increase dopamine. I have seen Macuna Prurens as part of herbal medicines for premature ejaculation. If your premature ejaculation is combined with ED, then increasing the dopamine is worth trying.

E. Norepinephrine is known as the arousal and orgasm neurotransmitter. It is synthesized from dopamine. It causes stress, anxiety and hypertension. Make sure your stress and anxiety is not causing it to increase. Have good sleep and exercise. Use anxiety herbs like passion flower, Valerian etc.
Note: If you also have insomnia, then most probably your norepinephrine is high.

F. Nitric Oxide is also very important to relax the smooth muscles and calm the nerves. If you have erection problems or erectile dysfunction associated with premature ejaculation, then you are low in nitric oxide. That is whey nitric oxide boosting herbs are also part of premature ejaculation food supplements.
In today's advanced world, L-Arginine/Citrulline is a miracle for boosting nitric oxide. It is widely used supplement in the muscle building community because high levels of nitric oxide are required for building and healing muscles.
Ashwagandha, pomegranate, watermelon is good for increasing nitric oxide production.


Mineral Imbalance
Mineral Imbalance is another important factor in premature ejaculation. It greatly affects the neurotransmitter balance.
Zinc, Magnesium, Potassium, Selenium, Copper, Manganese, Calcium etc., are also very important.
Almonds, nuts are important for healthy nervous system and contain balanced minerals like magnesium, potassium and calcium etc.
Zinc and magnesium deficiencies have both been linked to low testosterone levels. Zinc has also been shown to prevent the body from converting testosterone into estrogen. Both zinc and magnesium are involved in hundreds of biochemical processes in the body.

Zinc reduces stress hormone secretion
Role of Zinc in Serotonin
Magnesium deficiency has a possible role in premature ejaculation

Vitamin D Deficiency: If you live indoors, you should check your vitamin D levels. It hinders the absorption of calcium etc., and as a result mineral imbalance happens. Testosterone becomes low, histamine rises and you get into an array of problems.

Zinc Deficiency: Look into it. It might be the reason for your low serotonin levels.

Summary:
If you are making slow progress with pelvic floor exercises and edging etc, there is no harm in trying some supplements. If you have life long premature ejaculation, you must consider lowering your histamine levels. It is what causes spasms in the pelvic floor area and makes the mental arousal uncontrollable.

What a typical supplement for premature ejaculation looks like? It contains ingredients to lower histamine levels and increase serotonin, GABA and nitric oxide.

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Some good research to read:
http://stephanelarre.free.fr/DESC_Andro_PDF_Juin/Dysorders.pdf
http://pharmrev.aspetjournals.org/content/64/3/621.full
http://www.ncbi.nlm.nih.gov/pubmed/22378309

Good thread about increasing GABA:
http://autoimmunethyroid.wordpress.c...olar-disorder/
Propanolol 10 mg before an hour is used for premature ejaculation
Clonidine is also used for premature ejaculation combined with ssri
Shilajeet valium like effects: http://www.therdsf.org/wp-content/up...lijitNEW-1.pdf
http://sponauglewellness.com/wellnes...sorder-causes/