..Guidelines EVERYONE Should Read Before Medicating for E.D

[corageon Banned Find all posts View Profile Close corageon]

Exactly, and there are superfoods that act as natural PDE inhibitors; plenty of them. Dark Chocalate, Goldenseal (contains berberine), Horny Goat Weed (though you probably wouldn't eat it).... you get the feel.

Another lesser known PDE-5 inhibitor (natural) is known as "OSTHOLE" from the fruit of Cnidium Monnieri extract, unfortunately, getting a high Osthole percentage seems to be a hard task.

[corageon Banned Find all posts View Profile Close corageon]

PART FOUR AND CONCLUSIONS

Re-Instating 5-Alpha-Reductase Enzymes (for DHT production) after using Finasteride/Propecia.



RESOLVING POST-FINA SYNDROME.
You have to start at the roots.

Resolve any underlying hormone issues stemming from use of 5-AR Inhibitors.
This INCLUDES natural inhibitors such as BETA-SITOSTEROL and this potent natural 5-ARI is found in many MANY HERBS.

Quit eating SOY and other estrogenic / anti-DHT foods!

Maca contains beta-sitosterol, Suma as well...
Saw Palmetto, Pygeum, Stinging Nettle...all of these herbs if used improperly can cause estrogen dominance over time (a creeping, transient estrogen dominance).

To reinstate 5-AR/DHT function after using a 5-AR drug such as finasteride, you need to re-boot the enzymes 5-alpha-reductase while treating the consequential, cascading hormone imbalance caused by Anti-DHT drugs.

My advice is to get blood work and check if your estrogen is elevated first. If so, talk to your doctor about an aromatase inhibitor, which will help restore sexual function after Fina use.
If prolactin is elevated, either get some liquid prami or Cabergoline or take a supplement called "INHIBIT-P" (Inhibit Prolactin) by SNS (Serious Nutrition Solutions).

To re-instate 5-AR enzymes, read my DHT thread.
Specifically I recommend using a supplement called "Protodioscin" or high Potency tribulus extract.

Also, eating more saturated fats and cholesterol will help, as will lowering Cortisol levels.

Increasing free testosterone will also help bring out the DHT in you.

Lowering estrogen and prolactin is one way to do that.

The other is by using Divanil or a compound called "Proviron".

[corageon Banned Find all posts View Profile Close corageon]

PART FIVE
Paraventrical Nucleus and MPOA (Medial Preoptic Area) Dopamine Levels



Dopamine, the Medial Preoptic Area and Male Sexual Behavior

These are the two most important area's in regard to central sexual responsiveness, non-contact erections and libido.
At the moment, the current research shows that Testosterone and Estrogen are important regulators of MPOA dopamine - as well as DHT. (1) (2) (3)
However there are some non-hormonal factors, such as central histamine, opiates, nitric oxide and oxytocin. Neuropeptides such as Oxytocin and Vasopressin mediate the sexual responses triggered by both dopamine and serotonin, as well as histamine and glutamate. Oxytocin facilitates bonding and trust, as well as feelings of love - and vasopressin does a little bit of the opposite - with a tendency to drive sexual compulsion as opposed to emotional reactions.

However, both are very important chemicals.

Ways to Increase MPOA / PVN Dopamine.

-Ginkgo Biloba Extract (!) (!) (!)
-Raising Free Testosterone (!) (!)
-Modulating Serotonin Levels (!) (!) (!) (e.g Shilajit, Trazodone,Remeron,WAY 100,635)
-Opiate Antagonism (!) (!) (!) (!)
-Berberine Supplementation (!) (!)
-L-Dopa/Mucuna Pruriens Extract. (!) (!)
-DHT Precursors (!) (!)
-Icariin Extract (!)


Specific NeuroChemical Pathway.
The Inevitable.

Dopamine (D2,D3,D4) --> Oxytocin --> N-type Calcium Channels --> nNOS (Neuronal Nitric Oxide Synthase) --> Erection

Serotonin 5-HT2C --> Oxytocin --> N-Type Calcium --> nNOS --> Erection

Histamine H(2) R --> Oxytocin --> N-Type Calcium --> nNOS --> Erection

Brain T (Estradiol) (low-moderate concentration) --> D2 Dopamine and Serotonin 5-HT2C EXPRESSION Upregulated.
nNOS Proteins thus increased.

DHT ---> Local Penile Nitric Oxide (direct, independent, androgen mediated directly) (does not require Ca2+ or oxytocin)

Pregnenolone --> NMDA Activation --> Direct N-Type Calcium Activation ---> nNOS --> Erection

Beta-Adrenergic Activation --> Oxytocin ---> N-type Ca2+ --> nNOS --> Erection (milder than above though)...also stimulates local nitric oxide.



Opiates are negative modulators of both oxytocin and separate nitric oxide synthases. (!)

[corageon Banned Find all posts View Profile Close corageon]

Admins/Mods...stick this thread?

[corageon Banned Find all posts View Profile Close corageon]

Very informative thread. I have been a lurker for too long and need help from the good people that reside here. I am on Citalopram(40mgs), Propranolol(160mgs), hydrochlorothiazide(50mgs) and omneprazole(40mgs for gerd). Good lord most of these have an adverse effect on my ability to achieve an erection. Recently they added testosterone 100cc every 10-14days. I feel good, but I can not get an erection without viagra, cialis, levitra or staxyn, and that does not always work and the side effects on all of them are horrible...I take Levitra 20mgs now...I suffer the least on that and it works 75% of the time. I am 53 yrs old and have struggled with ED since my upper 30's. I need help, I am tired of trying to fix things with meds, its not working and I am at a loss. Please read my thread that I posted earlier today:

https://www.pegym.com/forums/erectil...ed-advice.html

I appreciate any guidance.

Talk to your doc about lowering the dose of citalopram or adding either Remeron or trazodone at night to augment the effects of it...preferably remeron between the doses of 30 and 45mg....you may also want to look into some dopaminergic supplements, but ofc talk to your doc first...usplabs powerFULL is a good one!
Same thing with the beta-blocker, you might want to switch to an ACE inhibitor or an alpha blocker, or even a calcium channel blocker.

[corageon Banned Find all posts View Profile Close corageon]

PART SIX (Will be working on this over the next couple days)
-----------------MANAGING H.P.T.A SHUTDOWN/HYPO-ACTIVITY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

~Restoring OPTIMAL TESTOSTERONE LEVELS~

Besides the tactics and methods mentioned before in this post/article ; lowering body fat and committing to a consistent resistance weight training program can have a profound impact on your free and Total testosterone.

Especially if this was a prior problem before of if you have a history of diabetes - this is one way to help remedy the entire picture.

Cardio-training and endurance exercises are ideal for those who have a history of heart disease in their family, but these workouts should be done early on to prevent the onset of disease and the decline in vascular function.

Additionally, it's worthwhile to say that building some muscle can help improve androgen receptor function and improve testosterone production as well.

Thus, EXERCISE , LIFT, HIT THAT IRON!!!
DO WHAT IT TAKES!

---------------------------------------------------------------------------------
The Concept of S.E.R.M.S ; Selective Estrogen Receptor Modulators
---------------------------------------------------------------------------------

Because SERMS like clomid and tamoxifen have been known to stimulate
testosterone production, and increase fertility in men, they have also been
the subject of giddy chatter on bodybuilding forums and where steroid use
is discussed. So to recovery, these tools work well!

The MOA is they mimic the action of estrogen selectively,
in certain tissues, and totally antagonize it (block receptors) in others such
as the pituitary so that the brain thinks there is very low estrogen, so it kicks up
testosterone production in order to make more estradiol (attempt to).


Interestingly, these compounds can also increase E2 (estrogen) levels , and so an additional modulation
such as an aromatase inhibitor may be necessary as part of the protocol to restore
natural testosterone production.

Finally, and perhaps most importantly, you don't need clomid or a pharmaceutical drug
to re-boot the HPA axis naturally. There is something called PHYTOSERMS 3-4-7 which has
natural SERMs to raise testosterone and fertility simultaneously.

!IMPORTANT NOTE!
Aromatase inhibition is strictly for those who have high estrogen levels in blood work, and a set of symptoms to go with it.

There is no need for an "average bear" to see aromatase inhibitors as some sort of "enhancement" UNLESS of course you are trying to lean out and are using natural methods...point is, pharmaceutical aromatase inhibitors are not of value for recreational use.


HELPFUL LINKS

Natural and Pharmaceutical Estrogen Blockers for Men


Natural Products as Aromatase Inhibitors

Aromatase inhibitors in men: effects and therapeutic options


Anti-Estrogen Diet for Men: Foods for Lowering Levels


Why Estrogen Balance is Critical to Aging Men

[corageon Banned Find all posts View Profile Close corageon]

I'm not sure why these threads were all merged into one top thread - IMO - this makes it a little more complicated, can we put all the main stickies back in order at the top, instead of merged? Makes things less accessible and organized IMO. Even if it did seem cluttered at first.

[corageon Banned Find all posts View Profile Close corageon]

Any ideas for 'ol corageon, now that he's back...?
I stiiill think this whole thing should be merged like it was before. (*sigh*)

[corageon Banned Find all posts View Profile Close corageon]

I still think we need to fix this SOB.

[BigO AdministratorPEGym Hero Find all posts View Profile Close BigO]

Corageon, are you referring to your post above, or the lists at the top of each forum?

[corageon Banned Find all posts View Profile Close corageon]

Corageon, are you referring to your post above, or the lists at the top of each forum?

I honestly think we should put the lists of stickies back up at the top, to me, it makes it more obscure this way and thus less accessible to some fellas.

[BigO AdministratorPEGym Hero Find all posts View Profile Close BigO]

The list is still there, just collected in one post now. This was done for a multitude of reasons, one being cleanliness.

Though it may require an additional click to access the list, the alternative was a rather unsightly overabundance of sticky threads in some forums.

With a now uniform location, lists of pertinent information can be given with a single thread location, as opposed to several.

We hear and appreciate your input, but still believe this is the best approach to correct the other concerns.

[Pegasus AdministratorPE Gym EditorPEGym Hero ☺ Admin of the Month Mar 2015 Find all posts View Profile Close Pegasus]

I see that you refer to anti estrogen and aging . Firstly is estrogen a common issue for ageing men ? If so what are good natural bang for buck methods to combat it.

[corageon Banned Find all posts View Profile Close corageon]

I see that you refer to anti estrogen and aging . Firstly is estrogen a common issue for ageing men ? If so what are good natural bang for buck methods to combat it.

Yes, but it's also ironically obscure and not been made much of a priority until recently. Even now, many Docs neglect to test for estradiol levels...it's even more important if on testosterone replacement therapy. The reason for this is given the multiple forms of hormone replacement; gels, shots of different forms and pills - there is much more room for error. It also makes treating patients a more complex task, especially if there are other factors to throw in like past alcoholism or a familial history of liver disease.

In which case pills are pretty much off the board and then there's the shots....easier on the liver, but some create more estrogen buildup than others depending on the release rate, brand name and ester used.

Transdermals can swing both ways - with some men complaining of more hair loss and such with these...and others find that bloating and other E2 related symptoms occur more.

Bottom line is it should be tested for more, but it's gonna take a while for it be received as it should be across the board. Estrogen is also likely to be a bigger issue if any of the following factors are at play.

-High body fat or overweight.
-Low DHT levels.
-Use of clonidine or alpha-2-agonists.
-Use of certain psychotropic and entactogen drugs.

These articles should give you a good idea of what to look for and how to go about it as well...

http://www.lef.org/Magazine/2010/5/W...ng-Men/Page-01
http://www.dcnutrition.com/miscellan...cordNumber=475
http://www.ncbi.nlm.nih.gov/pubmed/12198740

I would recommend increasing intake of fruits and other Vitamin C containing foods, drinking pomegranate juice daily, and if you have a mildly elevated estradiol level in which doesn't warrant a traditional AI - you can go for something like PES Erase or Triazole is a good one...mangosteen juice and pomegranate juice daily though is a good nutritional method.

Because estrogen is partially cortisol-dependent, you may want to also increase intake of sulfur containing foods to both rid the liver and intestines of estrogens and also it will help minimize glutamate toxicity which can lead to cortisol issues,.. and thus estrogen issues. Also of course, avoid or minimize stressful situations and stress in general!

[corageon Banned Find all posts View Profile Close corageon]

Also should be mentioned that besides lowering body fat, doing resistance exercise and CORE BODY WORKOUTS have an influence on how your body uses hormones, including estradiol. There's actually a HUGE contrast between the biorhythmical/chemical effects of core / moving exercises than 'still' lifting.