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  • #31
    Hi kpavel,

    I'm sorry to hear that. How are the things now, are you getting any better ?

    Corageon, I've stopped taking anything. Decided to give my body few weeks off anything but can't say I'm seeing much improvement. I feel hopeless and after reading some horror stories weird thoughts go through my mind. I still don't get the morning wood, sex is sometimes good but last time I couldn't get aroused at all, lost erection after few seconds.

    Regards

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    • #32
      Originally posted by corageon View Post
      Free T is certainly more important in regards to testosterone's cognitive, sexual and heart health benefits..however, regular testosterone, some BOUND is needed for muscle mass.....if you have extremely low SHBG - you are more susceptible to fat gain and estrogen dominance - UNLESS YOU HAVE LOW ESTRO TO BEGIN WITH....SHBG is a sex hormone REGULATING PROTEIN..unless you are PINNING testosterone - or have low levels of estrogen - crushing SHBG to undetectable is not a good idea...it is good to lower the levels of it(generally), but just don't eradicate it or obliterate it.

      Thanks for your insight, Kpavel.
      Indeed I have quite low estradiol levels. Mine were 18 at first measure, then lowered proportionally with testosterone to 13.6 and last time it was between 16 and 17. I took copper and stopped boron to increase. That's my suppose. My SHBG aim is between 20 and 30. I saw some info that estradiol is somehow connected with serotonin. Low estradiol is bad too according to LEF, Even more dangerous. It also has something with libido.

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      • #33
        Originally posted by Neuromancer View Post
        Hi kpavel,

        I'm sorry to hear that. How are the things now, are you getting any better ?

        Corageon, I've stopped taking anything. Decided to give my body few weeks off anything but can't say I'm seeing much improvement. I feel hopeless and after reading some horror stories weird thoughts go through my mind. I still don't get the morning wood, sex is sometimes good but last time I couldn't get aroused at all, lost erection after few seconds.

        Regards
        Things are the same as from near 7th of November. I tried dhea supplement for 10 days now to try raising testosterone and estradiol a little. My mood is good. As Jimmy Cliff sings 'you can get it if you really want'.
        I now use SAMe for neurotransmitters. It can raise both dopamine and serotonin indirectly. The best thing it
        really helps my mood and energy. I feel more power when lifting.
        If I were in America I would try to consult with Dr. Mariano from the definitivemind forum. Seems he knows a lot about hormones and neurotransmitters and he's an open-minded person. I would prepare everything I know: supplements I took for what time and all my symptoms and labs.
        Last edited by kpavel; 11-21-2014, 08:25 AM.

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        • #34
          Yesterday I was having several drinks of white wine. Today in the morning I felt seriously better morning erection and desire. Lasting time seems to increase too. Wine contains histamine and some good nutrients.

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          • #35
            Another progress made in my case. May be it will be helpful for someone. As I mentioned there was a problem with sensitivity after 5htp. I read quite enough about various supplements to help with ED. And already tried many of them. There was one supplement that I was afraid of because of strongly suspected methylation problems. That is b3 - niacin. Two weeks ago on Monday I gave 100 mg of Canadian niacin a try. And guess what? I felt subjectively that my penis is more alive in flaccid state! That was in a matter of hours! Another wonderful thing was it improved some slightly visible wrinkle under my eyes! I immediately made search on 5htp and vasoconstriction and found it really could create problems with skin. Also I found that niacin is made from huge amount of tryptophan. Estradiol initiates niacin production! Low estradiol - low niacin! Death rate in people with low estradiol is much higher than in those who have high lab values. So... women live longer because...)) And they have higher serotonin levels and they wait for orgasm longer. So-o...... I really have longer time before culmination and tried that with a woman already. Also niacin raises blood sugar and stimulates COMT which is theoretically good for me. During porn watch in first days of success I felt that my penis was a Soyuz rocket)) Now waiting how b3 can harm methyl health. But I never use more than 300 mg a day. It gives me flash from 100 mg. With 200 mg it's a strong one. Also I have more pleasurable orgasms now. Maybe because of some gaba sublingually. Libido and arousal is somewhat better too. Unfortunately my dick still has some feeling problems.(( Good luck!

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            • #36
              Originally posted by kpavel View Post
              Things are the same as from near 7th of November. I tried dhea supplement for 10 days now to try raising testosterone and estradiol a little. My mood is good. As Jimmy Cliff sings 'you can get it if you really want'.
              I now use SAMe for neurotransmitters. It can raise both dopamine and serotonin indirectly. The best thing it
              really helps my mood and energy. I feel more power when lifting.
              If I were in America I would try to consult with Dr. Mariano from the definitivemind forum. Seems he knows a lot about hormones and neurotransmitters and he's an open-minded person. I would prepare everything I know: supplements I took for what time and all my symptoms and labs.
              Low estrogen tends to cause the serotonin 5-HT(1) A receptors to upregulate, and genetically change, as well as oxytocin levels to either decrease or change in receptor expression; which causes low libido.....additionally, alpha-1-adrenergic receptors upregulate; responsible for the anxiety caused by low E2; similar to high estrogen, but less antagonizing forms of anxiety ensue.

              Altogether, what this means, is for some men, usually a majority, the effects on libido from low E2 come from unfavorable effects on serotonin receptors and adrenergic receptors - theoretically,. you can restore libido even with low estrogen - if we had 5-HT1A antagonists available, unfortunately, there is none on the market yet or that can be prescribed. There will be one available soon though, within a few months.

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              • #37
                more than a month ago discontinued niacin as it: 1)didn't work anymore; 2)i felt flat emotions, no joy
                two weeks before this started barberry root with milk thistle powder or without it sometimes.
                ordered supplements corageon writes about.
                after b3 discontinuation i felt obviously the best mood and tension relief i ever had these 5 years
                tried p5p 50-100 mg a day. it greatly increased libido, best of all. and more steady and quick erections. more and better thought erections. prolactin obviously. hardly cortisol (know from labs).
                a week ago started from the parcel: maca+berberine hcl thorne 500+500; in three days relora; in three days added korean ginseng 550+550.
                yesterday and today i feel f*cking tension in back of head. from 5htp research i highly suspect 5ht2a...
                some of these late three supplements seem to help with sagging skin under eyes (maybe was worse on niacin). don't know yet which. think about estradiol cortisol and serotonin...

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                • #38
                  if way100635 antagonizes presynaptic 5ht1a what's good with that? by the way curcumin seems to do the same.

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                  • #39
                    I should be wrong blaming ginseng in anxiety. I continued using it in the same dose and no tension effect. Maybe it was nescafe 3 in 1 I used. I feel tense on tyrosine and especially phenylalanine...
                    Last edited by kpavel; 04-13-2015, 11:42 PM.

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                    • #40
                      People blame curcumin in reducing their libido and if you search on Google for 'creatine libido' you will find creatine too may somehow influence libido for the bad side.
                      I added pyridoxine hcl up to 250 or 500 mg a day, histidine 500 mg, later horny goat weed (10% icariin from 1000 mg) 2-4 capsules.
                      The day I introduced hgw (unfortunately i'm very undisciplined) I decided to try inositol. Didn't have it since August cause I thought then it affects deepness of my voice. Makes me more anxious. (Yes, there are many opposite reviews)). And it's bad for testosterone. (Though I had TT 940 late August)).
                      So I took hgw (2 capsules) and a full teaspoon of cheap inositol powder.
                      I don't usually feel my morning erection very well (it's goog usually). That night I woke up with the same as written on a forum: 'It's interesting. I've been taking Lecithin (that contains Choline and Inositol) for two weeks, the only thing I've noticed is that I wake up in the middle of the night with massive erections. It hadn't happened for 25 years! I am not even sure if it's a good or a bad thing!' (Inositol [Archive] - Hair Loss Talk Support Forums). Searched pegym for inositol. Not much. Corageon wrote that berberine helped him. Another man called PharmD writes that inositol resensitized his 5ht1a autoreceptor units. Puzzzle.
                      With p5p and pyridoxine (or what I take additionally now) skin on penis is more 'elastic'. But now I do not notice spontaneous erections. They were with barberry root.

                      Comment


                      • #41
                        Originally posted by kpavel View Post
                        People blame curcumin in reducing their libido and if you search on Google for 'creatine libido' you will find creatine too may somehow influence libido for the bad side.
                        I added pyridoxine hcl up to 250 or 500 mg a day, histidine 500 mg, later horny goat weed (10% icariin from 1000 mg) 2-4 capsules.
                        The day I introduced hgw (unfortunately i'm very undisciplined) I decided to try inositol. Didn't have it since August cause I thought then it affects deepness of my voice. Makes me more anxious. (Yes, there are many opposite reviews)). And it's bad for testosterone. (Though I had TT 940 late August)).
                        So I took hgw (2 capsules) and a full teaspoon of cheap inositol powder.
                        I don't usually feel my morning erection very well (it's goog usually). That night I woke up with the same as written on a forum: 'It's interesting. I've been taking Lecithin (that contains Choline and Inositol) for two weeks, the only thing I've noticed is that I wake up in the middle of the night with massive erections. It hadn't happened for 25 years! I am not even sure if it's a good or a bad thing!' (Inositol [Archive] - Hair Loss Talk Support Forums). Searched pegym for inositol. Not much. Corageon wrote that berberine helped him. Another man called PharmD writes that inositol resensitized his 5ht1a autoreceptor units. Puzzzle.
                        With p5p and pyridoxine (or what I take additionally now) skin on penis is more 'elastic'. But now I do not notice spontaneous erections. They were with barberry root.
                        Hmmm..Better living through chemistry?

                        Comment


                        • #42
                          Also on March 11 my estradiol levels were 12.5 with testosterone 525.
                          And on April 13 E2 was 20.0 and T was 552. In the middle of February I began drinking black tea. But no estrogenic effect in the middle of the March. First days of April started sups mentioned above and stopped black tea. No caffeine except chocolate as always. And such effect.
                          Found this: Berberine Disturbs the Expression of Sex-hormone Regulated Genes in ?-naphthoflavone-induced Mice
                          Maybe it's because of a sudden increase of estrone conversion?
                          I know, black tea bad for DHT but all my childhood and youth I was drinking it daily with no problems. I decided to try lower cortisol with this. And reduced protein for this reason too...
                          Black tea is also a mild PDE5 inhibitor.
                          Last edited by kpavel; 04-17-2015, 12:24 PM.

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                          • #43
                            Originally posted by jockinthebox View Post
                            Hmmm..Better living through chemistry?
                            Better living eating only food of course. But when you're in trouble...

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                            • #44
                              Hi,

                              I was following the thread but unfortunately I haven't had any updates.

                              It's been almost 10 months since that day and I still do not get spontaneous erections and very rarely the morning ones. I feel much better, at least now I can get really good erection from watching porn. It's not the same as before where I get it only by touching my wife. Fortunately I get it before sex and this "thing" affected my PE in a positive way because it takes more time now to reach point of no return.

                              Last year I went to andrologist and he performed examination and an ultrasound scan. He said I don't have physical problems, have a very good blood flow towards the genitals and my problems are mental. He prescribed me Speman forte (Himalaya) 2 pills, twice per day. Whether because of the pills or something else I felt almost the same way as before, it took a month before I notice any change. Then I stopped them and since then I fell the same way as before the pills.

                              In the meanwhile I tried Cialis and have to say that is one miracle pill. Had sex twice the same night and wife was really really happy.

                              A friend of mine gave me "Black king kong" which is "certified" and produced in China, should have only herbs but FDA says it has similar ingredients as Viagra. I haven't tried it yet.

                              I believe I'm practicing healthy style of living, I don't smoke, drink occasionally and visit gym 2/3 times a week I refuse to belive this thing which happened last August is still affecting me.

                              I'm wondering whether I should try to increase my NO level based on carageon earlier advice. Mate if you are reading this, I would really appreciate on what you will say about this product:
                              Complete Nitric Oxide? | Nitric Oxide Booster Supplement UK | BULK POWDERS?

                              Thank you for reading!

                              Regards

                              Comment


                              • #45
                                Originally posted by corageon View Post
                                Low estrogen tends to cause the serotonin 5-HT(1) A receptors to upregulate, and genetically change, as well as oxytocin levels to either decrease or change in receptor expression; which causes low libido.....additionally, alpha-1-adrenergic receptors upregulate; responsible for the anxiety caused by low E2; similar to high estrogen, but less antagonizing forms of anxiety ensue.

                                Altogether, what this means, is for some men, usually a majority, the effects on libido from low E2 come from unfavorable effects on serotonin receptors and adrenergic receptors - theoretically,. you can restore libido even with low estrogen - if we had 5-HT1A antagonists available, unfortunately, there is none on the market yet or that can be prescribed. There will be one available soon though, within a few months.
                                450$ for 1g... hehe

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